People, Chemical Engineering, University of Utah
LEONARD F PEASE
More information on Leonard Pease may be found on the University of Utah's Faculty Profile Site.
Contact Information
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LEONARD F PEASE Assistant Professor Department of Chemical Engineering University of Utah
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Biographical Information
Appointments:
- Assistant Professor, Department of Chemical Engineering, University of Utah, 01/01/2009 to present.
- Adjunct Assistant Professor, Department of Internal Medicine, University of Utah, 09/06/2010 to present.
- Adjunct Assistant Professor, Department of Pharmaceutical Chemistry, University of Utah, 04/21/2009 to present.
- Member of the Nano Institute of Utah, Department of , University of Utah, 02/2009 to present.
Regions of Interest
- Central Asia, Eastern Asia, Northern Europe, Oceania.
Research
Research Summary:
1. Bionanomaterials synthesis and nanostructured materials characterization using electrospray differential mobility analysis. 2. Advanced medical technologies development (imaging, tissue engineering, drug delivery). 3. Analytical modeling of electrohydrodynamics, mass transfer, and kinetically aggregating systems. 4. Exploring nano/microtechnology for energy applications (algeal biofuels, nanophotonics, cellulosic substrate degradation, and polymeric nanopatterning). 5. Entrepreneurship.
Research Keywords:
- Nanotechnology and nanomedicine
- Nanostructured Materials
- Nanophotonics
- Nanoparticle Separations
- Medical or Diagnostic Imaging
- Mathematical Modeling
- Macromolecular assembly (virus ultra structure, amyloid fibrillation, etc.)
- Eosinophilic esophagitis
- Energy Engineering
- Computer Simulation or Modeling
- Biomass Fuels
Research Equipment:
- Differential Mobility Analysis--Characterizes nanoparticles by generating full particle size distributions with subnanometer resolution. It provides the multimodal resolution of TEM with the speed of light scattering. Useful for determining the aggregation state of nanoclusters and aggregates, the length distribution of fibers and nanotubes, the stoichiometry of virus antibody binding, soft coating on nanoparticles (DNA, polymers, self assembled monolayers, etc.), etc. We have also used this system to generate polymeric nanoparticles with a standard deviation of less than 1.5 nm..
Selected Publications
- Hedieh Saffari, Alexander Malugin, Hamid Ghandehari, Leonard F. Pease III, Electrostatic Deposition of Nanoparticles into Live Cell Culture Using An Electrospray Differential Mobility Analyzer, Journal of Aerosol Science (2011) in press.
- Suvajyoti Guha, Leonard F. Pease III, Kurt A. Brorson, Michael J. Tarlov, Michael R. Zachariah, Evaluation of Electrospray Differential Mobility Analysis for Virus Particle Analysis: Potential Applications for Biomanufacturing, Journal of Virological Methods 178 (2011) 201-208.
- Rajasekhar Anumolu, Leonard F. Pease III, Rapid Nanoparticle Characterization, in Nanoparticles, volume 2, Dr. Abbass Hashim, Ed., InTech Publishing, 2012, ISBN: 979-953-307-305-6, in press.
- Leonard F. Pease III, Physical Analysis of Virus Particles, Trends in Biotechnology (2011) submitted. Invited Review.
- Madhuvanthi Kandadai, Rajasekhar Anumolu, Xiaojun Wang, Durairaj Baskaran, Leonard F. Pease III, Dmitry Bedrov, Grant D. Smith, Jimmy W. Mays, Jules J. Magda, Polypeptide Grafted Hyaluronan: A Self-assembling Comb-branched Polymer Constructed from Biological Components, European Polymer Journal 47 (2011) 2022-2027.
- De-Hao Tsai, Daniel I. Lipin, Suvajyoti Guha, Jeremy I. Feldblyum, Kenneth D. Cole, Kurt A. Brorson, Michael R. Zachariah, Michael J. Tarlov, Anton P. J. Middelberg, Leonard F. Pease III, Process Analytical Technology for Recombinant Pandemic Flu Vaccines: Viral Ultrastructure, Aggregation, and Binding, Proceedings of the American Institute of Chemical Engineering 2011 Annual Meeting. CD-ROM. New York: AIChE, 2011.
- HyeongGon Kang, Matthew L. Clarke, Silvia H. De Paoli Lacerda, Leonard F. Pease III, Jeeseong Hwang, Time-correlated Hyperspectral Studies of Multiexciton Characteristics in Single and Dimeric Colloidal Quantum Dots during Photooxidation, Journal of Physical Chemistry C (2011) submitted.
- Martin Hollertz, John T. Elliott, Jacob Lewis, Eric R. Mansfield, Wynchester Whetten, Thomas A. Knotts IV, Michael J. Tarlov, Michael R. Zachariah, Leonard F. Pease III, Structural Differentiation of Oxytocin in Cyclical and Linear Conformations Using High Resolution Differential Mobility Analysis, Analytical Chemistry (2011) submitted.
- Hedieh Saffari, Alexander Malugin, Hamid Ghandehari, Leonard F. Pease III, Electrostatic Deposition of Nanoparticles into Live Cell Culture Using An Electrospray Differential Mobility Analyzer, Journal of Aerosol Science (2012) in press.
- Leonard F. Pease III, Optimizing the Yield and Selectivity of High Purity Nanoparticle Clusters, Journal of Nanoparticle Research 13 (2011) 2157-2172.
- Rajasekhar Anumolu, Joshua A. Gustafson, Jules J. Magda, Joseph Cappello, Hamidreza Ghandehari, Leonard F. Pease III, Fabrication of Highly Uniform Nanoparticles from Recombinant Silk-Elastin Polymers for Therapeutic Agent Delivery, ACS Nano 5 (2011) 5374-5382.
- Leonard F. Pease III, De-Hao Tsai, Kurt A. Brorson, Suvajyoti Guha, Michael R. Zachariah, Michael J. Tarlov, Physical Characterization of Viral Ultra Structure, Stability, and Integrity, Analytical Chemistry 83 (2011) 1753-1759.
- Leonard F. Pease III, Mirco Sorci, Suvajyoti Guha, De-Hao Tsai, Michael R. Zachariah, Michael J. Tarlov, Georges Belfort, Probing the Nucleus Model for Oligomer Formation During Insulin Amyloid Fibrilogenesis, Biophysical Journal 99 (2010) 3979-3985.
- Leonard F. Pease III, Jeremy I. Feldblyum, Silvia H. DePaoli Lacaerda, Rajesekhar Anumolu, Peter B. Yim, Matthew L. Clarke, HyeongGon Kang, Jeeseong Hwang, Structural Analysis of Soft Multicomponent Nanoparticle Clusters, ACS Nano 4 (2010) 6982-6988.
- Leonard F. Pease III, De-Hao Tsai, Rebecca A. Zangmeister, Joshua L. Hertz, Michael R. Zachariah, Michael J. Tarlov, Packing and Size Determination of Colloidal Nanoclusters, Langmuir 26 (2010) 11384-11390.
Selected Presentations
- (Invited) University of Oklahoma School of Chemical, Biological, and Materials Engineering Seminar. Synthesis and Characterization of Complex Nanostructured Materials. Norman, OK February 1-2, 2012. http://www.ou.edu/coe/cbme/Seminar/current.html
- Digestive Disease Week (DDW) 2011 Patchy Eosinophil Infiltration in An Eosinophilic Esophagectomy with Implications for Clinical Biopsy Ascertainment of EoE Patients. Chicago, IL, May 7, 2011. Poster.
- 15th International Symposium on Recent Advances in Drug Delivery Systems, Electrostatic Delivery of Size Separated Nanoparticles to Live Cell Culture. Salt Lake City, UT, February 14, 2011. Poster.
- 15th International Symposium on Recent Advances in Drug Delivery Systems, Fabrication of Highly Uniform Nanoparticles from Recombinant Silk-Elastin Polymers for Therapeutic Agent Delivery. Salt Lake City, UT, February 14, 2011. Poster.
- University of Utah Materials for Nanotechnology Seminar Series sponsored by The Nano Institute of Utah and the Department of Pharmaceutics & Pharmaceutical Chemistry Complex Nanomaterial Synthesis and Structural Characterization. Salt Lake City, UT, February 7, 2011.
- AIChE Annual Meeting Optimizing the Yield and Selectivity of Nanoparticle Clusters. Salt Lake City, UT, November 11, 2010.
- AIChE Annual Meeting Fabrication of Highly Uniform Nanoparticles from Recombinant Silk-Elastinlike Protein Polymers for Gene Delivery Applications. Salt Lake City, UT, November 10, 2010.
- AIChE Annual Meeting Rapid Characterization of the Length Distribution of Carbon Nanotubes. Salt Lake City, UT, November 10, 2010.
- AIChE Annual Meeting Cellular Viability After Electrostatic Deposition of Electrosprayed Nanoparticles. Salt Lake City, UT, November 10, 2010.
- University of Utah Industrial Advisory Board, Soft Nanomaterials Characterization Laboratory: An Introduction. Salt Lake City, UT, April 9, 2010.
- Brigham Young University Chemical Engineering Graduate Seminar Characterization of Bionanomaterials. Provo, UT, January 14, 2010.
Service & Outreach
Professional service
- Session Chair, AIChE 2011 Annual Meeting, Conference Program Chair for 08E00 Nanostructured Materials for Electronic and Photonic Applications II and Co-Chair for 08E00 Nanostructured Materials for Electronic and Photonic Applications I, American Institute of Chemical Engineering, 11/2010 to 12/2011.
- Session Chair, Session Chair for 5 Sessions on Nanomedicine and Drug Delivery I-V, American Institute of Chemical Engineers, 03/2010 to 12/2010.
- Virus Filtration Taskforce, Parenteral Drug Association
Internal service
- Committee Member, Member University of Utah Physical, Life & Applied Sciences Area Committee, June 2010 to June 2013, 06/2010 to 06/2013.
- Committee Member, Member of Chemical Engineering Department Undergraduate Committee, March 2010 to present, 03/2010 to 06/2015.
More information on Leonard Pease may be found on the University of Utah's Faculty Profile Site.
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