Faculty Profile


Himanshu Sant

Research Interests


Center For Biomedical MIcrofluidics

Microscale Instrumentation For Biochemical Analysis

Awards & Honors

Publications

  • Qian Zhou, Azur Azapagic, Austin Eiting, Seoyeon Won, Alexandra Boyadzhiev, Himanshu Sant, Deisy Cristina Carvalho Fernandes, Huanan Zhang. (2026). Mechanically robust PEDOT:PSS hydrogel via mild liquid metal crosslinking. Soft Matter, 22(22).
  • John McDaid, Julian E Bailes, Neilank K Jha, George Bobustuc, Reed Berlet, Cassidy Kessinger, Eliana Whitcomb, John M Lee, Daniil P Aksenov, Matthew Walker, Azur Azapagic, Jade Bookwalter, Ata Ullah, Himanshu Sant, Jill Shea, Bruce K Gale. (2026). Correction: Efficacy of local convection enhanced delivery of chemotherapy using an intracerebral osmotic pump in a rat model of glioblastoma. Frontiers in Oncology, 16.
  • John McDaid, Julian E Bailes, Neilank K Jha, George Bobustuc, Reed Berlet, Cassidy Kessinger, Eliana Whitcomb, John M Lee, Daniil P Aksenov, Matthew Walker, Azur Azapagic, Jade Bookwalter, Ata Ullah, Himanshu Sant, Jill Shea, Bruce K Gale. (2026). Efficacy of local convection enhanced delivery of chemotherapy using an intracerebral osmotic pump in a rat model of glioblastoma. Frontiers in Oncology, 16.
  • Reed Berlet, Azur Azapagic, Neilank K Jha, Daniil Aksenov, Jade Bookwalter, Ata Ullah, George Bobustuc, John Lee, Himanshu Sant, John McDaid, Matthew Walker, Jill Shea, Dylan Graff, Ann K Barlow, Roberta Frigerio, Daniel Aliee, Clint Bailes, Bruce K Gale, Julian E Bailes. (2025). An implantable, intracerebral osmotic pump for convection-enhanced drug delivery in glioblastoma multiforme. Frontiers in Oncology, 15.
  • Ata Ullah, Jade Bookwalter, Himanshu Sant, Azur Azapagic, Jill Shea, Reed Berlet, Neilank Jha, Julian Bailes, Bruce K Gale. (2025). An Osmosis-driven 3D-printed brain implant for drug delivery. Biomedical Microdevices, 27(3).
  • Yunhao Peng, Bruce K Gale, Himanshu J Sant. (2025). A spiral channel with integrated microelectrodes for label-free particle lateral position and size characterization. Biomedical Microdevices, 27(2).
  • Yunhao Peng, Bruce K Gale, Himanshu J Sant. (2025). Waterborne protozoan parasite detection using two-frequency impedance flow cytometry. Analytical Methods, 17(17).
  • Yunhao Peng, Bruce K Gale, Marc D Porter, Ling Zang, Himanshu J Sant. (2025). Modified trident-shaped electrode design for particle lateral position detection in microfluidic impedance flow cytometry. Sensors and Actuators A Physical, 381.
  • Azur Azapagic, Jayant Agarwal, Bruce Gale, Jill Shea, Himanshu Jayant Sant. (2024). A novel solvent-extruded tacrolimus-eluting suture for attenuated inflammation and scarring in skin repair. Journal of Drug Delivery Science and Technology, 102.
  • Ugochukwu Nze, Himanshu SANT, BRUCE GALE, Christopher Lambert, Dhruv Patel, Michael Beeman. (2024). Hydrodynamic Cavitation.
  • Azur Azapagic, Jayant Agarwal, Bruce Gale, Jill Shea, Susan Wojtalewicz, Himanshu Sant. (2024). A tacrolimus-eluting nerve guidance conduit enhances regeneration in a critical-sized peripheral nerve injury rat model. Biomedical Microdevices, 26(3).
  • Christopher J Lambert, Eamonn Clarke, Dhruv Patel, Lars B Laurentius, Bruce K Gale, Himanshu J Sant, Marc D Porter. (2024). Microfluidic platform for the enzymatic pretreatment of human serum for the detection of the tuberculosis biomarker mannose-capped lipoarabinomannan. Analytical Methods, 16(31).
  • Azur Azapagic, Jayant Agarwal, Bruce Gale, Huizhong Li, Samuel Nelson, Jill Shea, Himanshu Sant. (2024). A Novel Vascular Anastomotic Coupling Device for End-to-End Anastomosis of Arteries and Veins. IEEE Transactions on Biomedical Engineering, 71(2).
  • Lars B Laurentius, Eamonn Clarke, Christopher Lambert, Dhruv Patel, Tawsif Mahmood, Ling Zang, Himanshu Sant, Bruce K Gale, Marc D Porter. (2024). Chapter 46 Chip-based nanotechnology in the molecular pathology laboratory and beyond. Elsevier.
  • Dhruv Patel, Madison Hansen, Christopher Lambert, Shruti Hegde, Harikrishnan Jayamohan, Bruce K Gale, Himanshu Jayant Sant. (2023). Characterizing a Silver Nanoparticle-Based Electrochemical Biosensor for Shiga Toxin Detection. ACS Omega, 8(43).
  • Lars LAURENTIUS, Eamonn Clarke, Christopher Lambert, Dhruv Patel, Tawsif Mahmood, Ling ZANG, Himanshu SANT, BRUCE GALE, Marc PORTER. (2023). Chip-based nanotechnology in the molecular pathology laboratory and beyond. Academic Press.
  • Christopher J Lambert, Harikrishnan Jayamohan, Bruce K Gale, Lars B Laurentius, Dhruv Patel, Madison Hansen, Tawsif Mahmood, Himanshu Jayant Sant. (2023). Electrochemical Detection of SARS-CoV-2 Using Immunomagnetic Separation and Gold Nanoparticles on Unmodified Screen-Printed Carbon Electrodes. Applied Sciences, 13(18).
  • Sierra Erickson, Jonathan Vizmeg, Jack Shuckra, Susan Wojtalewicz, Andrew Cleveland, Jordan Davis, Michael Beeman, Stefan Niederauer, Himanshu Sant, Jayant Agarwal, Caleb Lade, Brett Davis. (2023). Effect of Active Pharmaceutical Ingredient, Lipid Composition, and Thermal Processing on the Physical Stability of Local Anesthetic-loaded Lipid Microparticles. Journal of Pharmaceutical Innovation, 18(3).
  • Brett Davis, Susan Wojtalewicz, Sierra Erickson, Jacob Veith, Andrew Simpson, Himanshu Sant, Jill Shea, Bruce Gale, Jay Agarwal. (2023). Local delivery of FK506 to a nerve allograft is comparable to systemic delivery at suppressing allogeneic graft rejection. PLOS ONE, 18(3).
  • Susan Wojtalewicz, Jonathon Vizmeg, Sierra Erickson, Caleb Lade, Jill Shea, Himanshu Sant, Jules Magda, Bruce Gale, Jayant Agarwal, Brett Davis. (2022). Evaluating the influence of particle morphology and density on the viscosity and injectability of a novel long-acting local anesthetic suspension. Journal of Biomaterials Applications, 37(4).
  • Dhruv Patel, Harikrishnan Jayamohan, Ugochukwu Nze, Christopher Lambert, Haidong Feng, Tawsif Mahmood, Bruce Gale, Himanshu Sant. (2022). Design of a hydrodynamic cavitation system for the extraction and detection of Escherichia coli (O157:H7) from ground beef. Sensors and Actuators B Chemical, 369.
  • Farhad Shiri, Haidong Feng, Kevin E Petersen, Himanshu Sant, Gina T Bardi, Luke A Schroeder, Michael L Merchant, Bruce K Gale, Joshua L Hood. (2022). Separation of U87 glioblastoma cell-derived small and medium extracellular vesicles using elasto-inertial flow focusing (a spiral channel). Scientific Reports, 12(1).
  • Kevin Petersen, Farhad Shiri, Tonguc Onur Tasci, Himanshu Sant, Joshua Hood, Bruce Gale. (2021). Experiment, theory, and simulation of a flow-electrical-split flow thin particle separation device. Journal of Chromatography A, 1659.
  • John Nelson, Dev Patel, Himanshu J Sant, Jill Shea, Bruce K Gale, Jay Agarwal. (2021). Compression of the vascular wall to create a friction fit in a vascular anastomotic coupler. Journal of the Mechanical Behavior of Biomedical Materials, 123.
  • Farhad Shiri, Bruce K Gale, Himanshu Sant, Brody King, Gina T Bardi, Joshua L Hood, Kevin E Petersen. (2021). Development and Testing of a Continuous Flow-Electrical-Split-Flow Lateral Transport Thin Separation System (Fl-El-SPLITT). Analytical Chemistry, 93(5).
  • Pratima Labroo, Scott Ho, Himanshu Sant, Jill E Shea, Jayant Agarwal, Bruce Gale. (2021). Modeling diffusion-based drug release inside a nerve conduit in vitro and in vivo validation study. Drug Delivery and Translational Research, 11(1).
  • Harikrishnan Jayamohan, Christopher J Lambert, Himanshu J Sant, Alexander Jafek, Dhruv Patel, Haidong Feng, Michael Beeman, Tawsif Mahmood, Ugochukwu Nze, Bruce K Gale. (2021). SARS-CoV-2 pandemic: a review of molecular diagnostic tools including sample collection and commercial response with associated advantages and limitations. Analytical and Bioanalytical Chemistry, 413(1).
  • Haidong Feng, Matthew Hockin, Mario Capecchi, Bruce Gale, Himanshu Sant. (2020). Size and shape based chromosome separation in the inertial focusing device. Biomicrofluidics, 14(6).
  • Brett Davis, Sierra Erickson, Susan Wojtalewicz, Andrew Simpson, Cameron Metcalf, Himanshu Sant, Jill Shea, Bruce Gale, Jayant Agarwal. (2020). Entrapping bupivacaine-loaded emulsions in a crosslinked-hydrogel increases anesthetic effect and duration in a rat sciatic nerve block model. International Journal of Pharmaceutics, 588.
  • Farhad Shiri, Bruce K Gale, Himanshu Sant, Gina T Bardi, Joshua L Hood, Kevin E Petersen. (2020). Characterization of Human Glioblastoma versus Normal Plasma-Derived Extracellular Vesicles Preisolated by Differential Centrifugation Using Cyclical Electrical Field-Flow Fractionation. Analytical Chemistry, 92(14).
  • Haidong Feng, Matthew Hockin, Shuhua Zhang, Mario Capecchi, Bruce Gale, Himanshu Sant. (2020). Enhanced chromosome extraction from cells using a pinched flow microfluidic device. Biomedical Microdevices, 22(2).
  • Brett Davis, Sierra Erickson, Susan Wojtalewicz, Andrew Simpson, Himanshu Sant, Jill Shea, Bruce Gale, Jay Agarwal. (2020). Abstract 59: Injectable Extended Release Local Anesthetic Drug Delivery System For The Treatment Of Post-operative Pain. Plastic & Reconstructive Surgery Global Open, 8(4 Suppl).
  • Brett Davis, Sierra Erickson, Susan Wojtalewicz, Andrew Simpson, Himanshu Sant, Jill Shea, Bruce Gale, Jay Agarwal. (2020). Abstract 59: Injectable Extended Release Local Anesthetic Drug Delivery System For The Treatment Of Post-operative Pain. Plastic and reconstructive surgery. Global open, 8(4 Suppl).
  • Brett Davis, David Hilgart, Sierra Erickson, Pratima Labroo, Joshua Burton, Himanshu Sant, Jill Shea, Bruce Gale, Jay Agarwal. (2019). Local FK506 delivery at the direct nerve repair site improves nerve regeneration. Muscle & Nerve, 60(5).
  • Scott Ho, Pratima Labroo, Keng-Min Lin, Himanshu Sant, Jill Shea, Bruce Gale, Jay Agarwal. (2019). Designing a Novel Drug Delivering Nerve Guide: A Preliminary Study. Journal of Medical and Biological Engineering, 39(3).
  • Ugochukwu C Nze, Michael G Beeman, Christopher J Lambert, Ghadhanfer Salih, Bruce K Gale, Himanshu J Sant. (2019). Hydrodynamic cavitation for the rapid separation and electrochemical detection of Cryptosporidium parvum and Escherichia coli O157:H7 in ground beef. Biosensors and Bioelectronics, 135.
  • Brett Davis, David Hilgart, Sierra Erickson, Pratima Labroo, Joshua Burton, Himanshu Sant, Jill Shea, Bruce Gale, Jay Agarwal. (2019). Abstract 88: Local Delivery of FK506 to a Mouse Sciatic Nerve Injury Increases Nerve Regeneration Outcomes. Plastic & Reconstructive Surgery Global Open, 7(4 Suppl).
  • Brett Davis, David Hilgart, Sierra Erickson, Pratima Labroo, Joshua Burton, Himanshu Sant, Jill Shea, Bruce Gale, Jay Agarwal. (2019). Abstract 88: Local Delivery of FK506 to a Mouse Sciatic Nerve Injury Increases Nerve Regeneration Outcomes. Plastic and reconstructive surgery. Global open, 7(4 Suppl).
  • Pratima Labroo, David Hilgart, Brett Davis, Christopher Lambert, Himanshu Sant, Bruce Gale, Jill E Shea, Jayant Agarwal. (2019). Drug‐delivering nerve conduit improves regeneration in a critical‐sized gap. Biotechnology and Bioengineering, 116(1).
  • Kevin E Petersen, Farhad Shiri, Travis White, Gina T Bardi, Himanshu Sant, Bruce K Gale, Joshua L Hood. (2018). Exosome Isolation: Cyclical Electrical Field Flow Fractionation in Low-Ionic-Strength Fluids. Analytical Chemistry, 90(21).
  • Ryan Brewster, Bruce K Gale, Himanshu J Sant, Ken Monson, Jill Shea, Jay Agarwal. (2018). A Biodegradable Vascular Coupling Device for End-to-End Anastomosis. Journal of Medical and Biological Engineering, 38(5).
  • Michael G Beeman, Ugochukwu C Nze, Himanshu J Sant, Hammad Malik, Swomitra Mohanty, Bruce K Gale, Krista Carlson. (2018). Electrochemical Detection of E. coli O157:H7 in Water after Electrocatalytic and Ultraviolet Treatments Using a Polyguanine-Labeled Secondary Bead Sensor. Sensors, 18(5).
  • Ching-Wen Li, Brett Davis, Jill Shea, Himanshu Sant, Bruce Kent Gale, Jayant Agarwal. (2018). Optimization of micropatterned poly(lactic-co-glycolic acid) films for enhancing dorsal root ganglion cell orientation and extension. Neural Regeneration Research, 13(1).
  • Brett Davis, Susan Wojtalewicz, Pratima Labroo, Jill Shea, Himanshu Sant, Bruce Gale, Jayant Agarwal. (2018). Controlled release of FK506 from micropatterned PLGA films: potential for application in peripheral nerve repair. Neural Regeneration Research, 13(7).
  • Pratima Labroo, Jill Shea, Kyle Edwards, Scott Ho, Brett Davis, Himanshu Sant, Isak Goodwin, Bruce Gale, Jay Agarwal. (2017). Novel drug delivering conduit for peripheral nerve regeneration. Journal of Neural Engineering, 14(6).
  • Pratima Labroo, Ching-wen Li, Himanshu Sant, Bruce Gale, Jill E Shea, Jayant Agarwal. (2017). Abstract P29. Plastic & Reconstructive Surgery Global Open, 5(4S).
  • Pratima Labroo, Ching-wen Li, Himanshu Sant, Bruce Gale, Jill E Shea, Jayant Agarwal. (2017). Abstract P29: Self Contained Bioreactor For Bone Regeneration. Plastic and reconstructive surgery. Global open, 5(4 Suppl).
  • Pratima Labroo, Jill Shea, Himanshu Sant, Bruce Gale, Jayant Agarwal. (2017). Effect Of combining FK506 and neurotrophins on neurite branching and elongation. Muscle & Nerve, 55(4).
  • (2017). Abstract 134: FK506 Delivering Conduit For Peripheral Nerve Regeneration. Plastic and reconstructive surgery. Global open, 5(4 Suppl).
  • Pratima Labroo, Jill E Shea, Brett Davis, David Hilgart, Christopher Lambert, Himanshu Sant, Bruce Gale, Jayant Agarwal. (2017). Abstract 134. Plastic & Reconstructive Surgery Global Open, 5(4S).
  • (2017). Abstract 132: Effect Of Ngf Delivering Conduit On Peripheral Nerve Regeneration. Plastic and reconstructive surgery. Global open, 5(4 Suppl).
  • Pratima Labroo, Isak Goodwin, Brett Davis, Kyle Edwards, Scott Ho, Himanshu J Sant, Bruce K Gale, Jill E Shea, Jayant Agarwal. (2017). Abstract 132. Plastic & Reconstructive Surgery Global Open, 5(4S).
  • Huizhong Li, Bruce Gale, Jill Shea, Himanshu Sant, Christi M Terry, Jay Agarwal. (2017). Vascular Coupling System for End-to-End Anastomosis: An In Vivo Pilot Case Report. Cardiovascular Engineering and Technology, 8(1).
  • Pratima Labroo, Scott Ho, Himanshu Sant, Jill Shea, Bruce K Gale, Jay Agarwal. (2016). Controlled Delivery of FK506 to Improve Nerve Regeneration. Shock, 46(3S).
  • Victoria Ragsdale, Huizhong Li, Himanshu Sant, Tim Ameel, Bruce K Gale. (2016). A disposable, continuous-flow polymerase chain reaction device: design, fabrication and evaluation. Biomedical Microdevices, 18(4).
  • Keng-Min Lin, Jill Shea, Bruce K Gale, Himanshu Sant, Patti Larrabee, Jay Agarwal. (2016). Nerve growth factor released from a novel PLGA nerve conduit can improve axon growth. Journal of Micromechanics and Microengineering, 26(4).
  • Yan Deng, Jiao Chen, Yi Zhao, Xiaohui Yan, Li Zhang, Kwongwai Choy, Jun Hu, Himanshu J Sant, Bruce K Gale, Tao Tang. (2016). Transdermal Delivery of siRNA through Microneedle Array. Scientific Reports, 6(1).
  • Huizhong Li, Cody Gehrke, Bruce K Gale, Himanshu Sant, Brittany Coats, Jay Agarwal. (2015). A New Vascular Coupler Design for End-to-End Anastomosis: Fabrication and Proof-of-Concept Evaluation. Journal of Medical Devices, 9(3).
  • Huizhong Li, Bruce K Gale, Himanshu Sant, Jill Shea, E David Bell, Jay Agarwal. (2015). A Novel Vascular Coupling System for End-to-End Anastomosis. Cardiovascular Engineering and Technology, 6(3).
  • Harikrishnan Jayamohan, Bruce K Gale, Bj Minson, Christopher J Lambert, Neil Gordon, Himanshu J Sant. (2015). Highly Sensitive Bacteria Quantification Using Immunomagnetic Separation and Electrochemical Detection of Guanine-Labeled Secondary Beads. Sensors, 15(5).
  • Jayant P Agarwal, Himanshu J Sant. (2014). Drug Delivery for Peripheral Nerve Regeneration.
  • Li Yan, Anthony P Raphael, Xiaoyue Zhu, Beilei Wang, Wei Chen, Tao Tang, Yan Deng, Himanshu J Sant, Guangyu Zhu, Kwong Wai Choy, Bruce K Gale, Tarl W Prow, Xianfeng Chen. (2014). Nanocomposite‐Strengthened Dissolving Microneedles for Improved Transdermal Delivery to Human Skin. Advanced Healthcare Materials, 3(4).
  • Li Yan, Anthony P Raphael, Xiaoyue Zhu, Beilei Wang, Wei Chen, Tao Tang, Yan Deng, Himanshu J Sant, Guangyu Zhu, Kwong Wai Choy, Bruce K Gale, Tarl W Prow, Xianfeng Chen. (2014). Vaccine Delivery: Nanocomposite‐Strengthened Dissolving Microneedles for Improved Transdermal Delivery to Human Skin (Adv. Healthcare Mater. 4/2014). Advanced Healthcare Materials, 3(4).
  • Wei Chen, Chong Wang, Li Yan, Longbiao Huang, Xiaoyue Zhu, Bing Chen, Himanshu J Sant, Xinrui Niu, Guangyu Zhu, K N Yu, V A L Roy, Bruce K Gale, Xianfeng Chen. (2014). Improved polyvinylpyrrolidone microneedle arrays with non-stoichiometric cyclodextrin. Journal of Materials Chemistry B, 2(12).
  • Cody Gehrke, Huizhong Li, Himanshu Sant, Bruce Gale, Jay Agarwal. (2014). Design, fabrication and testing of a novel vascular coupling device. Biomedical Microdevices, 16(1).
  • (2013). A Cross-Flow Split-Thin-Flow Cell.
  • Harikrishnan Jayamohan, Himanshu J Sant, Bruce K Gale. (2013). Applications of Microfluidics for Molecular Diagnostics. Methods in Molecular Biology, 949.
  • Himanshu J Sant, Siddharth Chakravarty, Srinivas Merugu, Colin G Ferguson, Bruce K Gale. (2012). Characterization of Polymerized Liposomes Using a Combination of dc and Cyclical Electrical Field-Flow Fractionation. Analytical Chemistry, 84(19).
  • Srinivas Merugu, Himanshu J Sant, Bruce K Gale. (2012). Diffusion Split-Flow Thin Cell (SPLITT) system for protein separations. Journal of Chromatography B, 902.
  • Srinivas Merugu, Himanshu J Sant, Bruce K Gale. (2012). A novel method for effective field measurements in electrical field‐flow fractionation. Electrophoresis, 33(6).
  • Himanshu J Sant, Bruce K Gale. (2012). Optimization and characterization of a microscale thermal field-flow fractionation system. Sensors and Actuators B Chemical, 162(1).
  • Himanshu J Sant, Bruce K Gale. (2012). Characterization of a microscale thermal–electrical field-flow fractionation system. Journal of Chromatography A, 1225.
  • R Samuel, H J Sant, F Jiao, C R Johnson, B K Gale. (2011). Microfluidic laminate-based phantom for diffusion tensor-magnetic resonance imaging. Journal of Micromechanics and Microengineering, 21(9).
  • Merugu Srinivas, Himanshu J Sant, Bruce K Gale. (2010). Optimization of cyclical electrical field flow fractionation. Electrophoresis, 31(20).
  • Himanshu J Sant, Tammy Ho, Bruce K Gale. (2010). An in situ heater for a phase-change-material-based actuation system. Journal of Micromechanics and Microengineering, 20(8).
  • Sarah A Molokhia, Himanshu Sant, Jacquelyn Simonis, C J Bishop, R M Burr, Bruce K Gale, Balamurali K Ambati. (2010). The capsule drug device: Novel approach for drug delivery to the eye. Vision Research, 50(7).
  • Himanshu J Sant, Bruce K Gale. (2009). Flexible fabrication, packaging, and detection approach for microscale chromatography systems. Sensors and Actuators B Chemical, 141(1).
  • Himanshu J Sant, Bruce K Gale. (2007). Microscale Field-Flow Fractionation: Theory and Practice. Springer Nature.
  • Himanshu J Sant, Jung Woo Kim, Bruce K Gale. (2006). Reduction of End Effect-Induced Zone Broadening in Field-Flow Fractionation Channels. Analytical Chemistry, 78(23).
  • Himanshu J Sant, Bruce K Gale. (2006). Geometric scaling effects on instrumental plate height in field flow fractionation. Journal of Chromatography A, 1104(1-2).
  • Himanshu J Sant, Bruce K Gale. (2001). A Microfabricated Thermo-Electrical Field Flow Fractionation System. Springer Nature.