Thomas Zangle

Publications

• Kholod A Elhasany, Shukran Alizada, Sushanto Kumar Saha, Thomas A Zangle, Abigail Pulsipher, Hamid Ghandehari. (2026). Abstract 4625: Mechanistic insights into the radioprotective action of GM-0111 via CCL5 inhibition and endothelial-immune modulation. Cancer Research, 86(7_Supplement).
• Rebecca G Zitnay, Shukran Alizada, Tarek E Moustafa, Devin Lange, Luke Schreiber, Alexander Lex, Robert L Judson‐Torres, Thomas A Zangle, Rachel L Belote. (2026). QUILPEN Provides Independent and Label‐Free Single‐Cell Quantification of Pigmentation Dynamics and Organelle Content. Pigment Cell & Melanoma Research, 39(2).
• Saha SK, Alizada S, Zangle TA, Ghandehari H. (2026). Quantitative phase imaging analysis of silica nanoparticle-induced macrophage recovery and functionality.. Nanomedicine (London, England), pp. 1-10.
• Yuntian Zhang, Marcus A Urquijo, Rebecca G Zitnay, Kayla Marks, Rachel L Belote, Maike M K Hansen, Montana Ferita, Hannah M Neuendorf, Tong Liu, Eric A Smith, Elnaz Mirzaei Mehrabad, Miroslav Hejna, Tarek E Moustafa, Devin Lange, Min Hu, Fatemeh Vand-Rajabpour, Anne Done, Carly A Becker, Matthew Lieberman, Matthew Chang, Brian K Lohman, Chris J Stubben, Melissa Q Reeves, Xiaoyang Zhang, Leor S Weinberger, Matthew W VanBrocklin, Dekker C Deacon, Douglas Grossman, Benjamin T Spike, Alexander Lex, Glen M Boyle, Rajan Kulkarni, Thomas A Zangle, Robert L Judson-Torres. (2025). A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma. Cell Reports, 44(12).
• Saranne J Mitchell, Carlos Pardo-Pastor, Anastassia Tchoumakova, Thomas A Zangle, Jody Rosenblatt. (2025). Energy deficiency selects crowded live epithelial cells for extrusion. Nature, 646(8087).
• Rebecca G Zitnay, Shukran Alizada, Anastasia Prokofyeva, Thomas A Zangle, Robert L Judson-Torres. (2025). Quantitative Phase Imaging for Assessing Tumor Cell Adaptability. Taylor & Francis.
• Devin Lange, Robert Judson-Torres, Thomas A Zangle, Alexander Lex. (2025). Aardvark: Composite Visualizations of Trees, Time-Series, and Images. IEEE Transactions on Visualization and Computer Graphics, 31(1).
• Eric A Smith, Rachel L Belote, Nelly M Cruz, Tarek E Moustafa, Carly A Becker, Amanda Jiang, Shukran Alizada, Anastasia Prokofyeva, Tsz Yin Chan, Tori A Seasor, Michael Balatico, Emilio Cortes-Sanchez, David H Lum, John R Hyngstrom, Hanlin Zeng, Dekker C Deacon, Allie H Grossmann, Richard M White, Thomas A Zangle, Robert L Judson-Torres. (2024). Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment. Journal of Experimental & Clinical Cancer Research, 43(1).
• Tarek E Moustafa, Rachel L Belote, Edward R Polanco, Robert L Judson-Torres, Thomas A Zangle. (2024). Quadrant darkfield for label-free imaging of intracellular puncta. Journal of Biomedical Optics, 29(11).
• Alyssa L Harpring, Soorya Pradeep, Thomas A Zangle. (2024). Comparison of automated and manual intracellular particle tracking using quantitative phase imaging.. Journal of the Optical Society of America A, 41(11).
• Jingzhou Zhang, Justin Griffin, Koushik Roy, Alexander Hoffmann, Thomas A Zangle. (2024). Tracking of lineage mass via quantitative phase imaging and confinement in low refractive index microwells. Lab on a Chip, 24(18).
• Soorya Pradeep, Thomas A Zangle. (2024). LVING reveals the intracellular structure of cell growth. Scientific Reports, 14(1).
• Moustafa TE, Belote RL, Polanco ER, Judson-Torres RL, Zangle TA. (2024). Quadrant darkfield for label-free imaging of intracellular puncta.. Journal of biomedical optics, 29(11), pp. 116501.
• Lange D, Judson-Torres R, Zangle TA, Lex A. (2024). Aardvark: Composite Visualizations of Trees, Time-Series, and Images.. IEEE transactions on visualization and computer graphics, PP.
• Smith EA, Belote RL, Cruz NM, Moustafa TE, Becker CA, Jiang A, Alizada S, Prokofyeva A, Chan TY, Seasor TA, Balatico M, Cortes-Sanchez E, Lum DH, Hyngstrom JR, Zeng H, Deacon DC, Grossmann AH, White RM, Zangle TA, Judson-Torres RL. (2024). Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment.. Journal of experimental & clinical cancer research : CR, 43(1), pp. 317.
• Chelsea U Kidwell, Joseph R Casalini, Soorya Pradeep, Sandra D Scherer, Daniel Greiner, Defne Bayik, Dionysios C Watson, Gregory S Olson, Justin D Lathia, Jarrod S Johnson, Jared Rutter, Alana L Welm, Thomas A Zangle, Minna Roh-Johnson. (2023). Transferred mitochondria accumulate reactive oxygen species, promoting proliferation. eLife, 12.
• Tarek E Moustafa, Edward R Polanco, Rachel L Belote, Robert L Judson-Torres, Thomas A Zangle. (2023). Fabrication and validation of an LED array microscope for multimodal, quantitative imaging. HardwareX, 13.
• Thang L Nguyen, Soorya Pradeep, Robert L Judson-Torres, Jason Reed, Michael A Teitell, Thomas A Zangle. (2022). Quantitative Phase Imaging: Recent Advances and Expanding Potential in Biomedicine. ACS Nano, 16(8).
• Edward R Polanco, Tarek E Moustafa, Andrew Butterfield, Sandra D Scherer, Emilio Cortes-Sanchez, Tyler Bodily, Benjamin T Spike, Bryan E Welm, Philip S Bernard, Thomas A Zangle. (2022). Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer. Communications Biology, 5(1).
• Soorya Pradeep, Thomas A Zangle. (2022). Quantitative phase velocimetry measures bulk intracellular transport of cell mass during the cell cycle. Scientific Reports, 12(1).
• Tarek E Moustafa, Edward R Polanco, Andrew Butterfield, Sandra D Scherer, Bryan E Welm, Philip S Bernard, Thomas A Zangle. (2021). Abstract 1301: Real-time single-cell drug response assay in metastatic breast cancer cell lines using quantitative phase imaging. Cancer Research, 81(13_Supplement).
• (2021). Loon: Using Exemplars to Visualize Large Scale Microscopy Data,.
• Soorya Pradeep, Tasmia Tasnim, Huanan Zhang, Thomas A Zangle. (2021). Simultaneous measurement of neurite and neural body mass accumulation via quantitative phase imaging. Analyst, 146(4).
• Edward R Polanco, Justin Griffin, Thomas A Zangle. (2021). Fabrication and Bonding of Refractive Index Matched Microfluidics for Precise Measurements of Cell Mass. Polymers, 13(4).
• (2021). Identifying Desirable T Lymphocytes by Change in Mass Responses.
• Thang L Nguyen, Edward R Polanco, Alexander N Patananan, Thomas A Zangle, Michael A Teitell. (2020). Cell viscoelasticity is linked to fluctuations in cell biomass distributions. Scientific Reports, 10(1).
• Dian Huang, Irena J Roy, Graeme F Murray, Jason Reed, Thomas A Zangle, Michael A Teitell. (2019). Identifying fates of cancer cells exposed to mitotic inhibitors by quantitative phase imaging. Analyst, 145(1).
• Lynnea R Waters, Fasih M Ahsan, Johanna ten Hoeve, Jason S Hong, Diane N H Kim, Aspram Minasyan, Daniel Braas, Thomas G Graeber, Thomas A Zangle, Michael A Teitell. (2019). Ampk regulates IgD expression but not energy stress with B cell activation. Scientific Reports, 9(1).
• Huang D, Roy IJ, Murray GF, Reed J, Zangle TA, Teitell MA. (2019). Identifying fates of cancer cells exposed to mitotic inhibitors by quantitative phase imaging.. The Analyst, 145(1), pp. 97-106.
• Waters LR, Ahsan FM, Ten Hoeve J, Hong JS, Kim DNH, Minasyan A, Braas D, Graeber TG, Zangle TA, Teitell MA. (2019). Ampk regulates IgD expression but not energy stress with B cell activation.. Scientific reports, 9(1), pp. 8176.
• Edward R Polanco, Nicholas Western, Thomas A Zangle. (2018). Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics. Journal of Visualized Experiments(139).
• Edward R Polanco, Nicholas Western, Thomas A Zangle. (2018). Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics.. Journal of Visualized Experiments(139).
• (2018). Correction for Mitchell et al., Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America, 115(36).
• Simon Mitchell, Koushik Roy, Thomas A Zangle, Alexander Hoffmann. (2018). Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America, 115(12).
• Dian Huang, Kevin A Leslie, Daniel Guest, Olga Yeshcheulova, Irena J Roy, Marco Piva, Gatien Moriceau, Thomas A Zangle, Roger S Lo, Michael A Teitell, Jason Reed. (2018). High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity. Analytical Chemistry, 90(5).
• Huang D, Leslie KA, Guest D, Yeshcheulova O, Roy IJ, Piva M, Moriceau G, Zangle TA, Lo RS, Teitell MA, Reed J. (2018). High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity.. Analytical chemistry, 90(5), pp. 3299-3306.
• Mitchell S, Roy K, Zangle TA, Hoffmann A. (2018). Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation.. Proceedings of the National Academy of Sciences of the United States of America, 115(12), pp. E2888-E2897.
• Diane N H Kim, Kevin T Kim, Carolyn Kim, Michael A Teitell, Thomas A Zangle. (2018). Soft lithography fabrication of index-matched microfluidic devices for reducing artifacts in fluorescence and quantitative phase imaging. Microfluidics and Nanofluidics, 22(1).
• Diane N H Kim, Michael A Teitell, Jason Reed, Thomas A Zangle. (2015). Hybrid random walk-linear discriminant analysis method for unwrapping quantitative phase microscopy images of biological samples. Journal of Biomedical Optics, 20(11).
• Thomas A Zangle, Michael A Teitell, Jason Reed. (2014). Live Cell Interferometry Quantifies Dynamics of Biomass Partitioning during Cytokinesis. PLOS ONE, 9(12).
• Thomas A Zangle, Michael A Teitell. (2014). Live-cell mass profiling: an emerging approach in quantitative biophysics. Nature Methods, 11(12).
• S Senese, Y C Lo, D Huang, T A Zangle, A A Gholkar, L Robert, B Homet, A Ribas, M K Summers, M A Teitell, R Damoiseaux, J Z Torres. (2014). Chemical dissection of the cell cycle: probes for cell biology and anti-cancer drug development. Cell Death & Disease, 5(10).
• Thomas A Zangle, Jennifer Chun, Jin Zhang, Jason Reed, Michael A Teitell. (2013). Quantification of Biomass and Cell Motion in Human Pluripotent Stem Cell Colonies. Biophysical Journal, 105(3).
• Thomas A Zangle, Daina Burnes, Colleen Mathis, Owen N Witte, Michael A Teitell. (2013). Quantifying Biomass Changes of Single CD8+ T Cells during Antigen Specific Cytotoxicity. PLOS ONE, 8(7).
• Jennifer Chun, Thomas A Zangle, Theodora Kolarova, Richard S Finn, Michael A Teitell, Jason Reed. (2012). Rapidly quantifying drug sensitivity of dispersed and clumped breast cancer cells by mass profiling. Analyst, 137(23).
• Jason Reed, Jennifer Chun, Thomas A Zangle, Sheraz Kalim, Jason S Hong, Sarah E Pefley, Xin Zheng, James K Gimzewski, Michael A Teitell. (2011). Rapid, Massively Parallel Single-Cell Drug Response Measurements via Live Cell Interferometry. Biophysical Journal, 101(5).
• Matthew E Suss, Ali Mani, Thomas A Zangle, Juan G Santiago. (2011). Electroosmotic pump performance is affected by concentration polarizations of both electrodes and pump. Sensors and Actuators A Physical, 165(2).
• Reed J, Chun J, Zangle TA, Kalim S, Hong JS, Pefley SE, Zheng X, Gimzewski JK, Teitell MA. (2011). Rapid, massively parallel single-cell drug response measurements via live cell interferometry.. Biophysical journal, 101(5), pp. 1025-31.
• Thomas A Zangle, Ali Mani, Juan G Santiago. (2010). Effects of Constant Voltage on Time Evolution of Propagating Concentration Polarization. Analytical Chemistry, 82(8).
• Daniel G Strickland, Matthew E Suss, Thomas A Zangle, Juan G Santiago. (2010). Evidence shows concentration polarization and its propagation can be key factors determining electroosmotic pump performance. Sensors and Actuators B Chemical, 143(2).
• Thomas A Zangle, Ali Mani, Juan G Santiago. (2010). Theory and experiments of concentration polarization and ion focusing at microchannel and nanochannel interfaces. Chemical Society Reviews, 39(3).
• Daniel G Strickland, Thomas Zangle, Juan Santiago. (2009). Visualization of Concentration Polarization Generated by Electroosmotic Pumps. ECS Meeting Abstracts, MA2009-01(41).
• Ali Mani, Thomas A Zangle, Juan G Santiago. (2009). On the Propagation of Concentration Polarization from Microchannel−Nanochannel Interfaces Part I: Analytical Model and Characteristic Analysis. Langmuir, 25(6).
• Thomas A Zangle, Ali Mani, Juan G Santiago. (2009). On the Propagation of Concentration Polarization from Microchannel−Nanochannel Interfaces Part II: Numerical and Experimental Study. Langmuir, 25(6).