Thomas Zangle

Publications

• A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma.
  Zhang Y, Urquijo MA, Zitnay RG, Marks K, Belote RL, Hansen MMK, Ferita M, Neuendorf HM, Liu T, Smith EA, Mehrabad EM, Hejna M, Moustafa TE, Lange D, H. Cell reports 2025 ; 44 12 : 116675

• QUILPEN provides independent and label-free single-cell quantification of pigmentation dynamics and organelle content.
  Zitnay RG, Alizada S, Moustafa TE, Lange D, Schreiber L, Lex A, Judson-Torres RL, Zangle TA, Belote RL. bioRxiv : the preprint server for biology 2025 ; :

• Determination of Drug Sensitivity in Patient Derived Models of Breast Cancer by Multiparametric QPI.
  Polanco ER, Moustafa TE, Balcioglu O, Scherer SD, Cortes-Sanchez E, Remick S, Spike BT, Welm AL, Welm BE, Bernard PS, Zangle TA. bioRxiv : the preprint server for biology 2025 ; :

• Energy deficiency selects crowded live epithelial cells for extrusion.
  Mitchell SJ, Pardo-Pastor C, Tchoumakova A, Zangle TA, Rosenblatt J. Nature 2025 ; :

• Marginal zone and follicular B cells respond differently to TLR4 and TLR9 stimulation.
  Makkar H, Remick S, Roy S, Zangle TA, Roy K. bioRxiv : the preprint server for biology 2025 ; :

• Comparison of automated and manual intracellular particle tracking using quantitative phase imaging.
  Harpring AL, Pradeep S, Zangle TA. Journal of the Optical Society of America. A, Optics, image science, and vision 2024 ; 41 11 : C49-C54

• Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment.
  Smith EA, Belote RL, Cruz NM, Moustafa TE, Becker CA, Jiang A, Alizada S, Prokofyeva A, Chan TY, Seasor TA, Balatico M, Cortes-Sanchez E, Lum DH, Hyng. Journal of experimental & clinical cancer research : CR 2024 ; 43 1 : 317

• Quadrant darkfield for label-free imaging of intracellular puncta.
  Moustafa TE, Belote RL, Polanco ER, Judson-Torres RL, Zangle TA. Journal of biomedical optics 2024 ; 29 11 : 116501

• Aardvark: Composite Visualizations of Trees, Time-Series, and Images.
  Lange D, Judson-Torres R, Zangle TA, Lex A. IEEE transactions on visualization and computer graphics 2024 ; PP :

• Tracking of lineage mass quantitative phase imaging and confinement in low refractive index microwells.
  Zhang J, Griffin J, Roy K, Hoffmann A, Zangle TA. Lab on a chip 2024 ; :

• LVING reveals the intracellular structure of cell growth.
  Pradeep S, Zangle TA. Scientific reports 2024 ; 14 1 : 8544

• Transferred mitochondria accumulate reactive oxygen species, promoting proliferation.
  Kidwell CU, Casalini JR, Pradeep S, Scherer SD, Greiner D, Bayik D, Watson DC, Olson GS, Lathia JD, Johnson JS, Rutter J, Welm AL, Zangle TA, Roh-John. eLife 2023 ; 12 :

• Fabrication and validation of an LED array microscope for multimodal, quantitative imaging.
  Moustafa TE, Polanco ER, Belote RL, Judson-Torres RL, Zangle TA. HardwareX 2023 ; 13 : e00399

• Quantitative phase velocimetry measures bulk intracellular transport of cell mass during the cell cycle.
  Pradeep S, Zangle TA. Scientific reports 2022 ; 12 1 : 6074

• Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer.
  Polanco ER, Moustafa TE, Butterfield A, Scherer SD, Cortes-Sanchez E, Bodily T, Spike BT, Welm BE, Bernard PS, Zangle TA. Communications biology 2022 ; 5 1 : 794

• Quantitative Phase Imaging: Recent Advances and Expanding Potential in Biomedicine.
  Nguyen TL, Pradeep S, Judson-Torres RL, Reed J, Teitell MA, Zangle TA. ACS nano 2022 ; :

• Loon: Using Exemplars to Visualize Large-Scale Microscopy Data.
  Lange D, Polanco E, Judson-Torres R, Zangle T, Lex A. IEEE transactions on visualization and computer graphics 2021 ; PP :

• Simultaneous measurement of neurite and neural body mass accumulation via quantitative phase imaging.
  Pradeep S, Tasnim T, Zhang H, Zangle TA. The Analyst 2021 ; 146 4 : 1361-1368

• Fabrication and Bonding of Refractive Index Matched Microfluidics for Precise Measurements of Cell Mass.
  Polanco ER, Griffin J, Zangle TA. Polymers 2021 ; 13 4 :

• Cell viscoelasticity is linked to fluctuations in cell biomass distributions.
  Nguyen TL, Polanco ER, Patananan AN, Zangle TA, Teitell MA. Scientific reports 2020 ; 10 1 : 7403

• Identifying fates of cancer cells exposed to mitotic inhibitors by quantitative phase imaging.
  Huang D, Roy IJ, Murray GF, Reed J, Zangle TA, Teitell MA. The Analyst 2019 ; 145 1 : 97-106

• Ampk regulates IgD expression but not energy stress with B cell activation.
  Waters LR, Ahsan FM, Ten Hoeve J, Hong JS, Kim DNH, Minasyan A, Braas D, Graeber TG, Zangle TA, Teitell MA. Scientific reports 2019 ; 9 1 : 8176

• High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity.
  Huang D, Leslie KA, Guest D, Yeshcheulova O, Roy IJ, Piva M, Moriceau G, Zangle TA, Lo RS, Teitell MA, Reed J. Analytical chemistry 2018 ; 90 5 : 3299-3306

• Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics.
  Polanco ER, Western N, Zangle TA. Journal of visualized experiments : JoVE 2018 ; 139 :

• Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation.
  Mitchell S, Roy K, Zangle TA, Hoffmann A. Proceedings of the National Academy of Sciences of the United States of America 2018 ; 115 12 : E2888-E2897

• Soft lithography fabrication of index-matched microfluidic devices for reducing artifacts in fluorescence and quantitative phase imaging.
  Kim DNH, Kim KT, Kim C, Teitell MA, Zangle TA. Microfluidics and nanofluidics 2018 ; 22 :

• Hybrid random walk-linear discriminant analysis method for unwrapping quantitative phase microscopy images of biological samples.
  Kim DN, Teitell MA, Reed J, Zangle TA. Journal of biomedical optics 2015 ; 20 11 : 111211

• Live cell interferometry quantifies dynamics of biomass partitioning during cytokinesis.
  Zangle TA, Teitell MA, Reed J. PloS one 2014 ; 9 12 : e115726

• Live-cell mass profiling: an emerging approach in quantitative biophysics.
  Zangle TA, Teitell MA. Nature methods 2014 ; 11 12 : 1221-8

• Quantification of biomass and cell motion in human pluripotent stem cell colonies.
  Zangle TA, Chun J, Zhang J, Reed J, Teitell MA. Biophysical journal 2013 ; 105 3 : 593-601

• Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity.
  Zangle TA, Burnes D, Mathis C, Witte ON, Teitell MA. PloS one 2013 ; 8 7 : e68916

• Rapidly quantifying drug sensitivity of dispersed and clumped breast cancer cells by mass profiling.
  Chun J, Zangle TA, Kolarova T, Finn RS, Teitell MA, Reed J. The Analyst 2012 ; 137 23 : 5495-8

• Rapid, massively parallel single-cell drug response measurements via live cell interferometry.
  Reed J, Chun J, Zangle TA, Kalim S, Hong JS, Pefley SE, Zheng X, Gimzewski JK, Teitell MA. Biophysical journal 2011 ; 101 5 : 1025-31

• Electroosmotic pump performance is affected by concentration polarizations of both electrodes and pump.
  Suss ME, Mani A, Zangle TA, Santiago JG. Sensors and actuators. A, Physical 2011 ; 165 2 : 310-315